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To evaluate the effect of a rapid initial glucose bolus on the pharmacokinetics and safety of mycophenolate mofetil, a new immunosuppressive agent for the treatment of acute and chronic rheumatoid arthritis, and to assess the pharmacokinetics of mycophenolic acid MPA alone and in combination with the small amounts of glucose present in the formulation of mycophenolate mofetil in rheumatoid arthritis patients with or without diabetes mellitus or with hyperglycemia.
A randomized, two-way crossover design was used to compare the pharmacokinetics of mycophenolate mofetil after ingestion of mg twice daily BID , when administered as a rapid initial bolus of 50 g glucose or as the usual formulation of 50 g glucose BID over 10 minutes.
MPA pharmacokinetics were assessed in blood samples collected over 24 hours. In a separate phase, steady-state pharmacokinetics of MPA were assessed over 14 days in 19 patients with rheumatoid arthritis and 14 with active systemic lupus erythematosus. The administration of a rapid initial glucose bolus as part of the usual formulation of mycophenolate mofetil does not alter the absorption of MPA. These data suggest that MPA is rapidly and almost completely absorbed following administration.
As the appearance of MPA into systemic circulation was the same following administration as the usual formulation, the elimination of MPA also appeared to be rapid. Molecular dynamics study of adsorption of hematite on negatively charged silica surfaces. Adobe Photoshop CS6. Free Download Operating System Windows. Requirements Windows All Versions. Related Posts More. PureRef for Mac.
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